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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: SYWC_HUMAN




USC-OGP 2-DE database:  SYWC_HUMAN


SYWC_HUMAN


General information about the entry
View entry in simple text format
Entry nameSYWC_HUMAN
Primary accession numberP23381
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Tryptophan--tRNA ligase, cytoplasmic; EC=6.1.1.2; AltName: Full=Interferon-induced protein 53; Short=IFP53; AltName: Full=Tryptophanyl-tRNA synthetase; Short=TrpRS; Short=hWRS; Contains: RecName: Full=T1-TrpRS; Contains: RecName: Full=T2-TrpRS;.
Gene nameName=WARS
Synonyms=IFI53, WRS
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.80; Mw=54833



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.80; Mw=53924
pI=5.76; Mw=51951



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=6.04; Mw=54840

Cross-references
UniProtKB/Swiss-ProtP23381; SYWC_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameSYWC_HUMAN
Primary accession numberP23381
Secondary accession number(s) A6NGN1 A6NID3 P78535 Q502Y0 Q53XB6 Q9UDI5 Q9UDL3
Sequence was last modified on December 1, 1992 (version 2)
Annotations were last modified on March 15, 2017 (version 176)
Name and origin of the protein
DescriptionRecName: Full=Tryptophan--tRNA ligase, cytoplasmic; EC=6.1.1.2; AltName: Full=Interferon-induced protein 53; Short=IFP53; AltName: Full=Tryptophanyl-tRNA synthetase; Short=TrpRS; Short=hWRS; Contains: RecName: Full=T1-TrpRS; Contains: RecName: Full=T2-TrpRS;
Gene nameName=WARS
Synonyms=IFI53, WRS
Encoded onName=WARS; Synonyms=IFI53, WRS
Keywords3D-structure; Alternative splicing; Aminoacyl-tRNA synthetase; Angiogenesis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM77804; AAA67324.1; -; mRNA
EMBLX59892; CAA42545.1; -; mRNA
EMBLM61715; AAA61298.1; -; mRNA
EMBLX62570; CAA44450.1; -; mRNA
EMBLBX248006; CAD62335.1; -; mRNA
EMBLAK056100; BAG51626.1; -; mRNA
EMBLAK291141; BAF83830.1; -; mRNA
EMBLAL157871; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471061; EAW81700.1; -; Genomic_DNA
EMBLBC017489; AAH17489.1; -; mRNA
EMBLBC095453; AAH95453.1; -; mRNA
EMBLS82905; AAB39381.1; -; Genomic_DNA
EMBLX67920; CAB94198.1; -; Genomic_DNA
EMBLX67921; CAB94198.1; JOINED; Genomic_DNA
EMBLX67922; CAB94198.1; JOINED; Genomic_DNA
EMBLX67923; CAB94199.1; -; Genomic_DNA
EMBLX67924; CAB94199.1; JOINED; Genomic_DNA
EMBLX67925; CAB94199.1; JOINED; Genomic_DNA
EMBLX67926; CAB94199.1; JOINED; Genomic_DNA
EMBLX67927; CAB94199.1; JOINED; Genomic_DNA
EMBLX67928; CAB94199.1; JOINED; Genomic_DNA
CCDSCCDS9960.1; -. [P23381-1]; .
CCDSCCDS9961.1; -. [P23381-2]; .
PIRA41633; A41706; .
RefSeqNP_004175.2; NM_004184.3. [P23381-1]; .
RefSeqNP_776049.1; NM_173701.1. [P23381-1]; .
RefSeqNP_998810.1; NM_213645.1. [P23381-2]; .
RefSeqNP_998811.1; NM_213646.1. [P23381-2]; .
RefSeqXP_005268101.1; XM_005268044.3. [P23381-1]; .
RefSeqXP_006720312.1; XM_006720249.3. [P23381-1]; .
RefSeqXP_011535435.1; XM_011537133.2. [P23381-1]; .
RefSeqXP_011535437.1; XM_011537135.2. [P23381-1]; .
RefSeqXP_011535438.1; XM_011537136.2. [P23381-2]; .
RefSeqXP_016877116.1; XM_017021627.1. [P23381-1]; .
RefSeqXP_016877117.1; XM_017021628.1. [P23381-1]; .
RefSeqXP_016877118.1; XM_017021629.1. [P23381-1]; .
UniGeneHs.497599; -; .
PDB1O5T; X-ray; 2.50 A; A=94-471
PDB1R6T; X-ray; 2.10 A; A/B=1-466
PDB1R6U; X-ray; 2.00 A; A/B=48-471
PDB1ULH; X-ray; 2.31 A; A/B=82-471
PDB2AKE; X-ray; 3.10 A; A=94-471
PDB2AZX; X-ray; 2.80 A; A/B=1-471
PDB2DR2; X-ray; 3.00 A; A=94-471
PDB2QUH; X-ray; 2.40 A; A/B=1-471
PDB2QUI; X-ray; 2.40 A; A/B=1-471
PDB2QUJ; X-ray; 2.42 A; A/B=1-471
PDB2QUK; X-ray; 2.80 A; A=1-471
PDBsum1O5T; -; .
PDBsum1R6T; -; .
PDBsum1R6U; -; .
PDBsum1ULH; -; .
PDBsum2AKE; -; .
PDBsum2AZX; -; .
PDBsum2DR2; -; .
PDBsum2QUH; -; .
PDBsum2QUI; -; .
PDBsum2QUJ; -; .
PDBsum2QUK; -; .
ProteinModelPortalP23381; -; .
SMRP23381; -; .
BioGrid113292; 60; .
DIPDIP-29493N; -; .
IntActP23381; 8; .
MINTMINT-1408962; -; .
STRING9606.ENSP00000347495; -; .
DrugBankDB00150; L-Tryptophan; .
DrugBankDB04537; L-Tryptophanamide; .
DrugBankDB01831; Tryptophanyl-5'amp; .
MoonProtP23381; -; .
iPTMnetP23381; -; .
PhosphoSitePlusP23381; -; .
SwissPalmP23381; -; .
BioMutaWARS; -; .
DMDM135191; -; .
OGPP23381; -; .
EPDP23381; -; .
MaxQBP23381; -; .
PaxDbP23381; -; .
PeptideAtlasP23381; -; .
PRIDEP23381; -; .
EnsemblENST00000344102; ENSP00000339485; ENSG00000140105. [P23381-2]; .
EnsemblENST00000355338; ENSP00000347495; ENSG00000140105. [P23381-1]; .
EnsemblENST00000358655; ENSP00000351481; ENSG00000140105. [P23381-2]; .
EnsemblENST00000392882; ENSP00000376620; ENSG00000140105. [P23381-1]; .
EnsemblENST00000556645; ENSP00000451887; ENSG00000140105. [P23381-2]; .
EnsemblENST00000557135; ENSP00000451460; ENSG00000140105. [P23381-1]; .
GeneID7453; -; .
KEGGhsa:7453; -; .
UCSCuc001yhg.3; human. [P23381-1]; .
CTD7453; -; .
DisGeNET7453; -; .
GeneCardsWARS; -; .
HGNCHGNC:12729; WARS; .
HPAHPA005573; -; .
HPAHPA018944; -; .
MIM191050; gene; .
neXtProtNX_P23381; -; .
OpenTargetsENSG00000140105; -; .
PharmGKBPA37340; -; .
eggNOGKOG2145; Eukaryota; .
eggNOGCOG0180; LUCA; .
GeneTreeENSGT00390000000666; -; .
HOVERGENHBG002325; -; .
InParanoidP23381; -; .
KOK01867; -; .
OMAFFFSHRD; -; .
OrthoDBEOG091G09U9; -; .
PhylomeDBP23381; -; .
TreeFamTF105669; -; .
BRENDA6.1.1.2; 2681; .
ReactomeR-HSA-379716; Cytosolic tRNA aminoacylation; .
ChiTaRSWARS; human; .
EvolutionaryTraceP23381; -; .
GeneWikiWARS_(gene); -; .
GenomeRNAi7453; -; .
PROPR:P23381; -; .
ProteomesUP000005640; Chromosome 14; .
BgeeENSG00000140105; -; .
CleanExHS_WARS; -; .
ExpressionAtlasP23381; baseline and differential; .
GenevisibleP23381; HS; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:HPA; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004830; F:tryptophan-tRNA ligase activity; NAS:UniProtKB; .
GOGO:0001525; P:angiogenesis; IEA:UniProtKB-KW; .
GOGO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc; .
GOGO:0045765; P:regulation of angiogenesis; IDA:UniProtKB; .
GOGO:0006412; P:translation; TAS:ProtInc; .
GOGO:0006418; P:tRNA aminoacylation for protein translation; TAS:Reactome; .
GOGO:0006436; P:tryptophanyl-tRNA aminoacylation; NAS:UniProtKB; .
CDDcd00806; TrpRS_core; 1; .
Gene3D1.10.287.10; -; 1; .
Gene3D3.40.50.620; -; 1; .
InterProIPR001412; aa-tRNA-synth_I_CS; .
InterProIPR002305; aa-tRNA-synth_Ic; .
InterProIPR014729; Rossmann-like_a/b/a_fold; .
InterProIPR009068; S15_NS1_RNA-bd; .
InterProIPR002306; Trp-tRNA-ligase; .
InterProIPR000738; WHEP-TRS_dom; .
PfamPF00579; tRNA-synt_1b; 1; .
PfamPF00458; WHEP-TRS; 1; .
PRINTSPR01039; TRNASYNTHTRP; .
SMARTSM00991; WHEP-TRS; 1; .
SUPFAMSSF47060; SSF47060; 1; .
TIGRFAMsTIGR00233; trpS; 1; .
PROSITEPS00178; AA_TRNA_LIGASE_I; 1; .
PROSITEPS00762; WHEP_TRS_1; 1; .
PROSITEPS51185; WHEP_TRS_2; 1; .



USC-OGP 2-DE database image


Gateways to other related servers


Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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